human DUS2L Over-expression AAV

Name 
AAV-h-DUS2L
Cat No 
AAV-207403
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human DUS2.

AAV-207403
AAV-h-DUS2L

Ready-to-use AAV expressing Human DUS2 (dihydrouridine synthase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Dihydrouridine synthase 2; dihydrouridine synthase 2-like, SMM1 homolog; DUS2L; hDUS2; SMM1; SMM1 homolog; tRNA-dihydrouridine synthase 2-like; tRNA-dihydrouridine(20) synthase (NAD(P)(+)); tRNA-dihydrouridine(20) synthase NAD(P)+-like; up-regulated in lung cancer protein 8; URLC8
Description (eCommerce)
DUS2, also known as DUS2L, encodes for tRNA-dihydrouridine(20) synthase [NAD(P)+]-like that catalyzes the synthesis of dihydrouridine. Dihydrouridine is a modified base found in the D-loop of most tRNAs [taken from UniProtKB (Entry: Q9NX74)].
Description (Vector)
Dihydrouridine synthase catalyzes reduction of the 5,6-double bond of a uridine residue on the displacement loop of tRNA. The resultant modified base, 5,6-dihydrouridine, appears to increase the conformational flexibility and dynamic motion of tRNA (Kato et al., 2005 (PubMed 15994936)).(supplied by OMIM, Mar 2008)
Gene ID
54920
Gene Name (eCommerce)
dihydrouridine synthase 2
Gene Name (Vector)
dihydrouridine synthase 2
Gene Symbol
DUS2
HGNC ID
HGNC:26014
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1482
ORF Size (bp)
1482 bp
Protein Name (eCommerce)
tRNA-dihydrouridine(20) synthase [NAD(P+)]-like
RefSeq ID
NM_017803
RefSeq Synonyms
NM_017803, NM_001271763, NM_001271762, BC006527,
Research Areas
Mitochondrion,RNA Binding,RNA Processing
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
DUS2, also known as DUS2L, encodes for tRNA-dihydrouridine(20) synthase [NAD(P)+]-like that catalyzes the synthesis of dihydrouridine. Dihydrouridine is a modified base found in the D-loop of most tRNAs [taken from UniProtKB (Entry: Q9NX74)].
UniGene ID
Hs.534460
UniProt ID (eCommerce)
Q9NX74

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.