human DNMT3A Over-expression AAV
This is an AAV expressing Human DNMT3A.
AAV-207210
AAV-h-DNMT3A
Ready-to-use AAV expressing Human DNMT3A (DNA methyltransferase 3 alpha). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DNA (cytosine-5-)-methyltransferase 3 alpha; DNA (cytosine-5)-methyltransferase 3A; DNA cytosine methyltransferase 3A2; DNA methyltransferase HsaIIIA; DNA MTase HsaIIIA; Dnmt3a; DNMT3A2; M.HsaIIIA; TBRS
Description (eCommerce)
DNA cytosine methyltransferase 3A2 (DNMT3A) is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. DNMT3A modifies DNA in a non-processive manner and also methylates non-CpG sites. It may preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. DNMT3A plays a role in paternal and maternal imprinting and is required for methylation of most imprinted loci in germ cells [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y6K1].
Description (Vector)
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene ID
1788
Gene Name (eCommerce)
DNA methyltransferase 3 alpha
Gene Name (Vector)
DNA methyltransferase 3 alpha
Gene Symbol
DNMT3A
HGNC ID
HGNC:2978
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2739
ORF Size (bp)
2739 bp
Protein Name (eCommerce)
DNA (cytosine-5)-methyltransferase 3A
RefSeq ID
NM_022552
RefSeq Synonyms
NM_175630, NM_175629, NM_153759, NM_022552, NM_001320893, NM_001320892, BC043617,
Research Areas
Cancer,Chromatin Remodeling,Epigenetic Regulation of Gene Expression,Gene Expression,Immunology,Methyltransferase,MicroRNAs in Cancer,Spermatogenesis,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,developmental_biology,genetics,immunology,transcription_translation
Species
human
Target Sentence
DNA cytosine methyltransferase 3A2 (DNMT3A) is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. DNMT3A modifies DNA in a non-processive manner and also methylates non-CpG sites. It may preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. DNMT3A plays a role in paternal and maternal imprinting and is required for methylation of most imprinted loci in germ cells [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9Y6K1].
UniGene ID
Hs.515840
UniProt ID (eCommerce)
Q9Y6K1
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.