human DMPK Over-expression AAV

Name 
AAV-h-DMPK
Cat No 
AAV-207093
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human DMPK.

AAV-207093
AAV-h-DMPK

Ready-to-use AAV expressing Human DMPK (dystrophia myotonica protein kinase). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
DM; DM1; DM1PK; DMK; MDPK; MT-PK
Description (Vector)
DMPK is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Gene ID
1760
Gene Name (Vector)
dystrophia myotonica protein kinase
Gene Symbol
DMPK
HGNC ID
HGNC:2933
ORF Size (aa)
1890
ORF Size (bp)
1890 bp
RefSeq ID
NM_004409
RefSeq Synonyms
NM_004409, NM_001288766, NM_001288765, NM_001288764, NM_001081563, NM_001081562, NM_001081560, BC062553, BC026328,
Species
human
UniGene ID
Hs.631596

Recently Viewed Products

AAV-h-DMRT3

Cat No: AAV-207097

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.