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human CUL1 Over-expression AAV

Name 
AAV-h-CUL1
Cat No 
AAV-206295
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human CUL1.

AAV-206295
AAV-h-CUL1

Ready-to-use AAV expressing Human CUL1 (cullin 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CUL-1; cullin-1
Description (eCommerce)
Cullin 1 (Cul1) is the core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, Cul1 serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. Cul1 may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13616].
Gene ID
8454
Gene Name (eCommerce)
cullin 1
Gene Name (Vector)
cullin 1
Gene Symbol
CUL1
HGNC ID
HGNC:2551
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2331
ORF Size (bp)
2331 bp
Protein Name (eCommerce)
Cullin-1
RefSeq ID
NM_003592
RefSeq Synonyms
NM_003592, BC125120, BC125119, BC034318,
Research Areas
Antigen Processing and Presentation,Apoptosis,B-cell Receptor Signaling,Cancer,Cell Cycle,Cytokine Signaling,Hedgehog Signaling,Host-Virus Interactions,Immunology,Interleukin Signaling,Meiosis,Neurobiology,Neurodegeneration,NF-kB Signaling,Notch Signaling,Parkinson's Disease,Parkin-Ubiquitin Proteasomal System,Prolactin Signaling,Signal Transduction,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Ubiquitination,Wnt Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
Cullin 1 (Cul1) is the core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, Cul1 serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. Cul1 may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13616].
UniGene ID
Hs.146806
UniProt ID (eCommerce)
Q13616

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.