human CSE1L Over-expression AAV

Name 
AAV-h-CSE1L
Cat No 
AAV-206100
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human CSE1L.

AAV-206100
AAV-h-CSE1L

Ready-to-use AAV expressing Human CSE1L (chromosome segregation 1 like). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CAS; cellular apoptosis susceptibility protein; chromosome segregation 1-like protein; CSE1; CSE1 chromosome segregation 1-like; epididymis secretory sperm binding protein; exp2; exportin-2; importin-alpha re-exporter; XPO2
Description (eCommerce)
CSE1 function to re-export importin-alpha to the cytoplasm after it has transported nuclear localization signal (NLS) containing proteins to the nucleus. CSE1 is also thought to play a role in cell proliferation and the mitotic spindle checkpoint.
Description (Vector)
Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene.
Gene ID
1434
Gene Name (eCommerce)
chromosome segregation 1 like
Gene Name (Vector)
chromosome segregation 1 like
Gene Symbol
CSE1L
HGNC ID
HGNC:2431
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2916
ORF Size (bp)
2916 bp
Protein Name (eCommerce)
Exportin-2
RefSeq ID
NM_001316
RefSeq Synonyms
NM_001316, NM_001256135, BC109314, BC109313, BC108309,
Research Areas
Apoptosis,Nuclear Import/Export,p53 Signaling,Signal Transduction,Transport
Research Areas (Faceted)
signal_transduction,cell_biology
Species
human
Target Sentence
CSE1 function to re-export importin-alpha to the cytoplasm after it has transported nuclear localization signal (NLS) containing proteins to the nucleus. CSE1 is also thought to play a role in cell proliferation and the mitotic spindle checkpoint.
UniGene ID
Hs.90073
UniProt ID (eCommerce)
P55060

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.