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human COX5A Over-expression AAV

Name 
AAV-h-COX5A
Cat No 
AAV-205834
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human COX5A.

AAV-205834
AAV-h-COX5A

Ready-to-use AAV expressing Human COX5A (cytochrome c oxidase subunit 5A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
COX; COX-VA; cytochrome c oxidase polypeptide Va; cytochrome c oxidase polypeptide, mitochondrial; cytochrome c oxidase subunit 5A, mitochondrial; cytochrome c oxidase subunit Va; mitochondrial cytochrome c oxidase subunit Va; VA
Description (eCommerce)
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. COX5A is the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme [taken from NCBI Entrez Gene (Gene ID: 9377)].
Description (Vector)
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme. A pseudogene COX5AP1 has been found in chromosome 14q22.
Gene ID
9377
Gene Name (eCommerce)
cytochrome c oxidase subunit 5A
Gene Name (Vector)
cytochrome c oxidase subunit 5A
Gene Symbol
COX5A
HGNC ID
HGNC:2267
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
453
Protein Name (eCommerce)
Cytochrome c oxidase subunit 5A, mitochondrial
RefSeq ID
NM_004255
RefSeq Synonyms
NM_004255, BC024240,
Research Areas
Alzheimer's Disease,Cardiology,Cardiovascular,Huntington's Disease,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,Neurodegeneration,Parkinson's Disease
Research Areas (Faceted)
neurobiology,cardiovascular,metabolism,cell_biology
Species
human
Target Sentence
Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer of proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. COX5A is the nuclear-encoded subunit Va of the human mitochondrial respiratory chain enzyme [taken from NCBI Entrez Gene (Gene ID: 9377)].
UniGene ID
Hs.401903
UniProt ID (eCommerce)
P20674

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.