human CHM Over-expression AAV

Name
AAV-h-CHM

Cat No
AAV-205156

Availability
4-5 weeks

This is an AAV expressing Human CHM.

AAV-205156

AAV-h-CHM

Ready-to-use AAV expressing Human CHM (CHM, Rab escort protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DXS540; GGTA; HSD-32; REP-1; TCD

Description (Vector)

CHM encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene ID

1121

Gene Name (Vector)

CHM, Rab escort protein 1

Gene Symbol

CHM

HGNC ID

HGNC:1940

ORF Size (aa)

1962

ORF Size (bp)

1962 bp

RefSeq ID

NM_000390

RefSeq Synonyms

NM_001320959, NM_001145414, NM_000390, BC172532, BC156457,

Species

human

UniGene ID

Hs.496449

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.