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human CDKL5 Over-expression AAV

Name 
AAV-h-CDKL5
Cat No 
AAV-204877
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human CDKL5.

AAV-204877
AAV-h-CDKL5

Ready-to-use AAV expressing Human CDKL5 (cyclin dependent kinase like 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CFAP247; cyclin dependent kinase 5 transcript; cyclin-dependent kinase-like 5; EIEE2; ISSX; serine/threonine kinase 9; serine/threonine-protein kinase 9; STK9
Description (eCommerce)
Cyclin-dependent kinase-like 5 (CDKL5) is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in the CDKL5 gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT) [taken from NCBI Entrez Gene (Gene ID: 6792)].
Description (Vector)
CDKL5 is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in this gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT). Alternate transcriptional splice variants have been characterized.
Gene ID
6792
Gene Name (eCommerce)
cyclin dependent kinase like 5
Gene Name (Vector)
cyclin dependent kinase like 5
Gene Symbol
CDKL5
HGNC ID
HGNC:11411
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3090
ORF Size (bp)
3090 bp
Protein Name (eCommerce)
Cyclin-dependent kinase-like 5
RefSeq ID
NM_003159
RefSeq Synonyms
NM_003159, NM_001323289, NM_001037343, BC152846,
Research Areas
BDNF Signaling,Epilepsy,Kinase/Phosphatase,Neurobiology,Neurodevelopment,RNA Processing
Research Areas (Faceted)
cell_biology,developmental_biology,genetics,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
Cyclin-dependent kinase-like 5 (CDKL5) is a member of Ser/Thr protein kinase family and encodes a phosphorylated protein with protein kinase activity. Mutations in the CDKL5 gene have been associated with X-linked infantile spasm syndrome (ISSX), also known as X-linked West syndrome, and Rett syndrome (RTT) [taken from NCBI Entrez Gene (Gene ID: 6792)].
UniGene ID
Hs.659851
UniProt ID (eCommerce)
O76039

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.