human CCL5 Over-expression AAV

Name
AAV-h-CCL5

Cat No
AAV-204464

Availability
4-5 weeks

This is an AAV expressing Human CCL5.

AAV-204464

AAV-h-CCL5

Ready-to-use AAV expressing Human CCL5 (C-C motif chemokine ligand 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

D17S136E; eoCP; RANTES; SCYA5; SIS-delta; SISd; TCP228

Description (Vector)

CCL5 is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor.

Gene ID

6352

Gene Name (Vector)

C-C motif chemokine ligand 5

Gene Symbol

CCL5

HGNC ID

HGNC:10632

ORF Size (aa)

276

RefSeq ID

NM_002985

RefSeq Synonyms

NM_002985, NM_001278736, BC008600,

Species

human

UniGene ID

Hs.514821

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.