human CASP5 Over-expression AAV
This is an AAV expressing Human CASP5.
AAV-204118
AAV-h-CASP5
Ready-to-use AAV expressing Human CASP5 (caspase 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ICE(rel)III; ICEREL-III; ICH-3
Description (Vector)
CASP5 encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene.
Gene ID
838
Gene Name (Vector)
caspase 5
Gene Symbol
CASP5
HGNC ID
HGNC:1506
ORF Size (aa)
1257
ORF Size (bp)
1257 bp
RefSeq ID
NM_004347
RefSeq Synonyms
NM_004347, NM_001136112, NM_001136110, NM_001136109, BC113406, BC074994,
Species
human
UniGene ID
Hs.213327
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.