human BIN1 Over-expression AAV

Name 
AAV-h-BIN1
Cat No 
AAV-202141
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human BIN1.

AAV-202141
AAV-h-BIN1

Ready-to-use AAV expressing Human BIN1 (bridging integrator 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AMPH2; amphiphysin II; amphiphysin-like protein; AMPHL; box dependant MYC interacting protein 1; box-dependent myc-interacting protein 1; Bridging integrator 1; CNM2; myc box-dependent-interacting protein 1; SH3P9
Description (eCommerce)
Bin1 (bridging integrator 1) may be involved in the regulation of synaptic vesicle endocytosis. It may act as a tumor suppressor and inhibits malignant cell transformation. Defects in BIN1 are the cause of centronuclear myopathy autosomal recessive (ARCNM) [taken from the Universal Protein Resource (UniProt) ww.uniprot.org/uniprot/O00499].
Description (Vector)
BIN1 encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described.
Gene ID
274
Gene Name (eCommerce)
bridging integrator 1
Gene Name (Vector)
bridging integrator 1
Gene Symbol
BIN1
HGNC ID
HGNC:1052
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1320
ORF Size (bp)
1320 bp
Protein Name (eCommerce)
Myc box-dependent-interacting protein 1
RefSeq ID
NM_004305
RefSeq Synonyms
NM_139351, NM_139350, NM_139349, NM_139348, NM_139347, NM_139346, NM_139345, NM_139344, NM_139343, NM_004305, NM_001320642, NM_001320641, NM_001320640, NM_001320634, NM_001320633, NM_001320632, BC004101,
Research Areas
Cancer,Cardiovascular,Cytoskeleton,Host-Virus Interactions,Neurobiology,Transport,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,infectious_disease,neurobiology
Species
human
Target Sentence
Bin1 (bridging integrator 1) may be involved in the regulation of synaptic vesicle endocytosis. It may act as a tumor suppressor and inhibits malignant cell transformation. Defects in BIN1 are the cause of centronuclear myopathy autosomal recessive (ARCNM) [taken from the Universal Protein Resource (UniProt) ww.uniprot.org/uniprot/O00499].
UniGene ID
Hs.193163
UniProt ID (eCommerce)
O00499

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.