human BAG3 Over-expression AAV

Name 
AAV-h-BAG3
Cat No 
AAV-201936
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human BAG3.

AAV-201936
AAV-h-BAG3

Ready-to-use AAV expressing Human BAG3 (BCL2 associated athanogene 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
BAG family molecular chaperone regulator 3; BAG-3; Bcl-2-associated athanogene 3; BCL2-binding athanogene 3; bcl-2-binding protein Bis; BIS; CAIR-1; docking protein CAIR-1; MFM6
Description (eCommerce)
BAG3 (BCL2-associated athanogene 3) BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. BAG3 contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All three proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner [taken from NCBI Entrez Gene (Gene ID: 9531)].
Description (Vector)
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
Gene ID
9531
Gene Name (eCommerce)
BCL2 associated athanogene 3
Gene Name (Vector)
BCL2 associated athanogene 3
Gene Symbol
BAG3
HGNC ID
HGNC:939
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1728
ORF Size (bp)
1728 bp
Protein Name (eCommerce)
BAG family molecular chaperone regulator 3
RefSeq ID
NM_004281
RefSeq Synonyms
NM_004281, BC107786, BC014656, BC006418,
Research Areas
Apoptosis,Brain Development,Cardiology,Cardiomyopathy,Cardiovascular,Neurobiology,Neurodevelopment,Protein Folding
Research Areas (Faceted)
cell_biology,neurobiology,developmental_biology,cardiovascular,neurobiology,developmental_biology,cell_biology
Species
human
Target Sentence
BAG3 (BCL2-associated athanogene 3) BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. BAG3 contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All three proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner [taken from NCBI Entrez Gene (Gene ID: 9531)].
UniGene ID
Hs.523309
UniProt ID (eCommerce)
O95817

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.