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human BACE1 Over-expression AAV

Name 
AAV-h-BACE1
Cat No 
AAV-201929
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human BACE1.

AAV-201929
AAV-h-BACE1

Ready-to-use AAV expressing Human BACE1 (beta-secretase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ASP2; BACE; HSPC104
Description (Vector)
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.
Gene ID
23621
Gene Name (Vector)
beta-secretase 1
Gene Symbol
BACE1
HGNC ID
HGNC:933
ORF Size (aa)
1506
ORF Size (bp)
1506 bp
RefSeq ID
NM_012104
RefSeq Synonyms
NM_138973, NM_138972, NM_138971, NM_012104, NM_001207049, NM_001207048, BC065492, BC036084,
Species
human
UniGene ID
Hs.504003

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.