human PRR5 Over-expression AAV

Name 
AAV-h-PRR5
Cat No 
AAV-201336
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PRR5.

AAV-201336
AAV-h-PRR5

Ready-to-use AAV expressing Human PRR5 (proline rich 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
FLJ20185k; PP610; proline rich 5 (renal); proline-rich protein 5; protein observed with Rictor-1; PROTOR1; PROTOR-1; Rho GTPase activating protein 8
Description (eCommerce)
Protein observed with Rictor (Protor-1) is a component of the mammalian target of rapamycin complex 2 (mTORC2). Protor-1 regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1 [taken from NCBI Entrez Gene (Gene ID: 55615)].
Description (Vector)
PRR5 encodes a protein with a proline-rich domain. PRR5 is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.
Gene ID
55615
Gene Name (eCommerce)
proline rich 5
Gene Name (Vector)
proline rich 5
Gene Symbol
PRR5
HGNC ID
HGNC:31682
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
864
Protein Name (eCommerce)
Proline-rich protein 5
RefSeq ID
NM_015366
RefSeq Synonyms
NM_181333, NM_015366, NM_001198721, NM_001017530, NM_001017529, NM_001017528, BC016921,
Research Areas
Cancer,Cell Cycle,mTOR Signaling,Signal Transduction,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,signal_transduction
Species
human
Target Sentence
Protein observed with Rictor (Protor-1) is a component of the mammalian target of rapamycin complex 2 (mTORC2). Protor-1 regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1 [taken from NCBI Entrez Gene (Gene ID: 55615)].
UniGene ID
Hs.102336
UniProt ID (eCommerce)
P85299

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.