human SOD1 shRNA Adenovirus
This is an pre-made gene silencing adenovirus that expresses a shRNA to knockdown human SOD1 gene. The shRNA expression is driven by an U6 promoter.
The knockdown of this human gene was validated by qPCR in A549 cells.
1859
Ad-h-SOD1-shRNA
Ready-to-use human SOD1 shRNA Adenovirus. human SOD1 shRNA adenovirus gene knockdown1859
Gene Reference Data
Alternate Names
ALS; ALS1; Cu/Zn superoxide dismutase; epididymis secretory protein Li 44; HEL-S-44; homodimer; hSod1; indophenoloxidase A; IPOA; SOD; SOD, soluble; superoxide dismutase Cu-Zn; Superoxide dismutase 1; superoxide dismutase 1, soluble; superoxide dismutase, cystolic
Description (eCommerce)
Superoxide dismutase 1 (SOD1) binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. SOD1 is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis [taken from NCBI Entrez Gene (Gene ID: 6647)].
Description (Vector)
SOD1 binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.
Gene ID
6647
Gene Name (eCommerce)
superoxide dismutase 1
Gene Name (Vector)
superoxide dismutase 1, soluble
Gene Symbol
SOD1
HGNC ID
HGNC:11179
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
465
Protein Name (eCommerce)
Superoxide dismutase [Cu-Zn]
RefSeq ID
NM_000454
RefSeq Synonyms
NM_000454, BC001034,
Research Areas
Aging,Amyotrophic Lateral Sclerosis (ALS),Apoptosis,Cancer,Cardiology,Cardiovascular,Cytoskeleton,DNA Damage/Repair,Huntington's Disease,IGF-1 Signaling,Immunology,Interleukin Signaling,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,Neurodegeneration,Neurodevelopment,Signal Transduction,Spermatogenesis
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,neurobiology,cardiovascular,cell_biology,genetics,transcription_translation,neurobiology,signal_transduction,immunology,metabolism,cell_biology,neurobiology,developmental_biology,cell_biology,cell_cycle
Species
human
Target Sentence
Superoxide dismutase 1 (SOD1) binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. SOD1 is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis [taken from NCBI Entrez Gene (Gene ID: 6647)].
UniGene ID
Hs.443914
UniProt ID (eCommerce)
P00441
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.