human CEACAM 1 shRNA Adenovirus
This is an pre-made gene silencing adenovirus that expresses a shRNA to knockdown human CEACAM 1 gene. The shRNA expression is driven by an U6 promoter.
The knockdown of this human gene was validated by qPCR in MBA-MB 468 cells.
1827
Ad-h-CEACAM 1-shRNA
Ready-to-use human CEACAM 1 shRNA Adenovirus. human CEACAM 1 shRNA adenovirus gene knockdown1827
Gene Reference Data
Alternate Names
antigen CD66; BGP; BGP1; BGP-1; BGPI; Biliary glycoprotein 1; carcinoembryonic antigen-related cell adhesion molecule 1; carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein); CD antigen CD66a; CD66a antigen
Description (eCommerce)
Carcinoembryonic antigen related cell adhesion molecules 1 and 5 (CEACAM1 and CEACAM5) are members of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. CEACAM1 was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. CEACAM5 is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, CEACAM5 may regulate differentiation, apoptosis, and cell polarity.
Description (Vector)
CEACAM1 encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined.
Gene ID
634
Gene Name (eCommerce)
carcinoembryonic antigen related cell adhesion molecule 1
Gene Name (Vector)
carcinoembryonic antigen related cell adhesion molecule 1
Gene Symbol
CEACAM1
HGNC ID
HGNC:1814
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1407
ORF Size (bp)
1407 bp
Protein Name (eCommerce)
Carcinoembryonic antigen-related cell adhesion molecule 1
RefSeq ID
NM_001712
RefSeq Synonyms
NM_001712, NM_001205344, NM_001184816, NM_001184815, NM_001184813, NM_001024912, BC014473,
Research Areas
Angiogenesis,Immunology,Signal Transduction
Research Areas (Faceted)
cancer,developmental_biology,immunology,signal_transduction
Species
human
Target Sentence
Carcinoembryonic antigen related cell adhesion molecules 1 and 5 (CEACAM1 and CEACAM5) are members of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. CEACAM1 was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. CEACAM5 is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, CEACAM5 may regulate differentiation, apoptosis, and cell polarity.
UniGene ID
Hs.512682
UniProt ID (eCommerce)
P13688
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.