human BECN1 shRNA Adenovirus
This is an pre-made gene silencing adenovirus that expresses a shRNA to knockdown human BECN1 gene. The shRNA expression is driven by an U6 promoter.
The knockdown of this human gene was validated by western blot in A549 cells.
1810
Ad-h-BECN1-shRNA
Ready-to-use human BECN1 shRNA Adenovirus. human BECN1 shRNA adenovirus gene knockdown1810
Gene Reference Data
Alternate Names
ATG6; ATG6 autophagy related 6 homolog; beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1, autophagy related; beclin1; beclin-1; coiled-coil myosin-like BCL2-interacting protein; Protein GT197; testis secretory sperm-binding protein Li 215e; VPS30
Description (eCommerce)
Beclin 1 was initially identified as a Bcl-2 interacting protein. Beclin 1 has been found to play a role in autophagy, the process whereby cellular structures, organelles, and intracellular pathogens undergo degradation. As an interacting protein of Bcl-2, beclin is able to influence Bcl-2 to function as an autophagy protein.
Description (Vector)
Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration (Zhong et al., 2009 (PubMed 19270693)).(supplied by OMIM, Jul 2010)
Gene ID
8678
Gene Name (eCommerce)
beclin 1
Gene Name (Vector)
beclin 1
Gene Symbol
BECN1
HGNC ID
HGNC:1034
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1353
ORF Size (bp)
1353 bp
Protein Name (eCommerce)
Beclin-1
RefSeq ID
NM_003766
RefSeq Synonyms
NM_003766, NM_001314000, NM_001313999, NM_001313998, BC010276,
Research Areas
Apoptosis,Autophagy,Cell Cycle,Cell Division,Golgi Apparatus,Host-Virus Interactions,Neurobiology,Neurodevelopment,Response to Virus
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology
Species
human
Target Sentence
Beclin 1 was initially identified as a Bcl-2 interacting protein. Beclin 1 has been found to play a role in autophagy, the process whereby cellular structures, organelles, and intracellular pathogens undergo degradation. As an interacting protein of Bcl-2, beclin is able to influence Bcl-2 to function as an autophagy protein.
UniGene ID
Hs.716464
UniProt ID (eCommerce)
Q14457
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.