VEGF Receptor 2 Adenovirus

Name 
Ad-VEGF-R2
Cat No 
1621
Availability
Immediate
Categories
Adenovirus, Over-Expression

Three cell membrane receptor tyrosine kinases Flt-1 (also designated VEGF-R1), Flk-1 (also designated VEGF-R2 or KDR) and Flt-4 (putatively involved in the growth of endothelial cells) are characterized by the presence of seven immunoglobulin-like sequences in their extracellular domains. Two members of this receptor class, Flt-1 and Flk-1, represent high affinity receptors for vascular endothelial growth factor (VEGF). On the basis of structural similarity to Flt-1 and Flk-1, Flt-4 may represent a third receptor for either VEGF or a VEGF-related ligand. Flt-3/ Flk-2 and its human homolog, STK-1, are expressed at high levels in hematopoietic cells and also in neural, gonadal, hepatic and placental tissues.

1621
Ad-VEGF-R2

Ready-to-use VEGF Receptor 2 Adenovirus. VEGFR2 VEGF-R2 adenovirus KDR FLK1 1621

$690.00
Request Volume Pricing or Customization

Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
CD309; FLK1; VEGFR; VEGFR2
Description (Vector)
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.
Gene ID
3791
Gene Name (Vector)
kinase insert domain receptor
Gene Symbol
KDR
HGNC ID
HGNC:6307
ORF Size (aa)
4071
ORF Size (bp)
4071 bp
RefSeq ID
NM_002253
RefSeq Synonyms
NM_002253, BC131822,
Species
human
UniGene ID
Hs.479756

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.