Complement component 1, q subcomponent, alpha polypeptide Adenovirus

Name 
Ad-C1q(A)
Cat No 
1604
Availability
Immediate
Categories
Adenovirus, Over-Expression

The complement component proteins, C3, C4, and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R, and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation, and cellular chemotaxis. Adipsin, also designated complement factor D, is a serine protease that cleaves complement factor B and may be involved in obesity. C1q, together with proenzymes C1r and C1s, yield C1, the first component of the serum complement system.

1604
Ad-C1q(A)

Ready-to-use Complement component 1, q subcomponent, alpha polypeptide Adenovirus. Ad-C1q(A), “Complement component 1, q subcomponent, alpha polypeptide”, C1qA, C1q(alpha), C1q(a), C1q A, C1q adenovirus 1604

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Description (Vector)
C1QA encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. C1QA encodes the A-chain polypeptide of human complement subcomponent C1q.
Gene ID
712
Gene Name (Vector)
complement C1q A chain
Gene Symbol
C1QA
HGNC ID
HGNC:1241
ORF Size (aa)
738
ORF Size (bp)
738 bp
RefSeq ID
NM_015991
RefSeq Synonyms
NM_015991, NM_001347466, NM_001347465, BC071986, BC030153,
Species
human
UniGene ID
Hs.632379

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.