IRAK4 Adenovirus

Name 
Ad-IRAK4
Cat No 
1578
Availability
Immediate
Categories
Adenovirus, Over-Expression

Interleukin-1 receptor (IL1R)-associated kinases (IRAKs) are important mediators in the signal transduction of Toll-like receptor (TLR) and IL-1R family members, collectively referred to as TIRs. Binding of IL-1 to its cognate receptor results in the activation of the NFkB signaling pathway. 100 kDa IRAK-1 is implicated as an upstream mediator of NFkB activation. IRAK-2 is a proximal mediator of IL-1, a component of the IL-1R signaling complex and is required for IL-1R-induced NFkB activation. IRAK-4 is strongly expressed in kidney and is also found in lung, testis, small intestine, breast, liver, and placenta. In contrast to the other IRAKs that are expressed in most cell types, IRAK-M is restricted to monocytic cells.

1578
Ad-IRAK4

Ready-to-use IRAK4 Adenovirus. Ad-IRAK4, IRAK4, IRAK4, REN64, NY-REN-64, IRAK-4 adenovirus 1578

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume
200 µL

Gene Reference Data

Alternate Names
IPD1; IRAK-4; NY-REN-64; REN64
Description (Vector)
IRAK4 encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
51135
Gene Name (Vector)
interleukin 1 receptor associated kinase 4
Gene Symbol
IRAK4
HGNC ID
HGNC:17967
ORF Size (aa)
1383
ORF Size (bp)
1383 bp
RefSeq ID
NM_016123
RefSeq Synonyms
NM_016123, NM_001145258, NM_001145257, NM_001145256, NM_001114182, BC013316,
Species
human
UniGene ID
Hs.138499

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.