Phosphatase and tensin homolog Adenovirus
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tension like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
1547
Ad-PTEN
Ready-to-use Phosphatase and tensin homolog Adenovirus. Ad-PTEN, Phosphatase and tensin homolog, BZS, MHAM, TEP1, MMAC1, PTEN1 adenovirus 1547
Gene Reference Data
Alternate Names
10q23del; BZS; CWS1; DEC; GLM2; MHAM; mitochondrial phosphatase and tensin protein alpha; mitochondrial PTENalpha; MMAC1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; phosphatase and tensin-like protein; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; protein tyrosine phosphatase; PTEN1; PTENbeta; TEP1
Description (eCommerce)
PTEN (phosphatase and tensin homolog) is a phosphatidylinositol-3,4,5-triphosphate 3-phosphatase that has been identified as a tumor suppressor. PTEN is a dual specificity tyrosine and serine/threonine phosphatase that preferentially dephosphorylates phosphoinositide substrates and negatively regulates the AKT/PKB signaling pathway. Through its action, PTEN has been shown to modulate cell cycle progression, cell survival, cell migration, cell adhesion, and insulin signaling.
Description (Vector)
PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
Gene ID
5728
Gene Name (eCommerce)
phosphatase and tensin homolog
Gene Name (Vector)
phosphatase and tensin homolog
Gene Symbol
PTEN
HGNC ID
HGNC:9588
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1212
ORF Size (bp)
1212 bp
Protein Name (eCommerce)
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
RefSeq ID
NM_000314
RefSeq Synonyms
NM_001304718, NM_001304717, NM_000314, BC005821,
Research Areas
Aging,Angiogenesis,Apoptosis,Autophagy,Axonogenesis,B-cell Receptor Signaling,Breast Cancer,Cancer,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,Cytoskeleton,DNA Damage/Repair,EGFR Signaling,EGFR Signaling in Cancer,Fc Receptor Signaling,FGF Signaling,Glioma,HGF Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Insulin Signaling,Kinase/Phosphatase,Lung Cancer,Metabolism/Metabolic Process,MicroRNAs in Cancer,mTOR Signaling,Neurobiology,Neurodevelopment,Neurogenesis,NGF Signaling,p53 Signaling,PDGF Signaling,Phosphatase,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,Prostate Cancer,Rho Signaling,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,Tumor Suppressors/Oncoproteins,Wnt Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,metabolism,neurobiology,signal_transduction,stem_cell_biology,transcription_translation
Species
human
Target Sentence
PTEN (phosphatase and tensin homolog) is a phosphatidylinositol-3,4,5-triphosphate 3-phosphatase that has been identified as a tumor suppressor. PTEN is a dual specificity tyrosine and serine/threonine phosphatase that preferentially dephosphorylates phosphoinositide substrates and negatively regulates the AKT/PKB signaling pathway. Through its action, PTEN has been shown to modulate cell cycle progression, cell survival, cell migration, cell adhesion, and insulin signaling.
UniGene ID
Hs.500466
UniProt ID (eCommerce)
P60484
Related Citations
- Downregulation of PTEN promotes podocyte endocytosis of lipids aggravating obesity-related glomerulopathy. Y Shi, etc, (2019), American Journal of Physiology-Renal Physiology
- Loss of PTEN promotes podocyte cytoskeletal rearrangement, aggravating diabetic nephropathy. J Lin, etc, (2015), The Journal of Pathology
- Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling. Beckham, TH. etc, (2013), Oncogenesis
- MADD is a downstream target of PTEN in triggering apoptosis. ayarama S. etc, (2013), Journal of Cellular Biochemistry
- Loss of PTEN induces microtentacles through PI3K-independent activation of cofilin. M I Vitolo, etc, (2012), Oncogene
- Ischemic preconditioning attenuates mitochondrial localization of PTEN induced by ischemia-reperfusion. Zu L, etc, (2011), Am J Physiol Heart Circ Physiol
- N-Myc Is A Novel Regulator Of Pi3k-Mediated Vegf Expression In Neuroblastoma. Kang J, etc, (2008), Oncogene
- Akt2 Overexpression Plays A Critical Role In The Establishment Of Colorectal Cancer Metastasis. Rychahou, PG. etc, (2008), PNAS
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.