Phosphatase and tensin homolog Adenovirus
This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tension like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway.
Ready-to-use Phosphatase and tensin homolog Adenovirus. Ad-PTEN, Phosphatase and tensin homolog, BZS, MHAM, TEP1, MMAC1, PTEN1 adenovirus 1547
Gene Reference Data
Related Citations
- Downregulation of PTEN promotes podocyte endocytosis of lipids aggravating obesity-related glomerulopathy. Y Shi, etc, (2019), American Journal of Physiology-Renal Physiology
- Loss of PTEN promotes podocyte cytoskeletal rearrangement, aggravating diabetic nephropathy. J Lin, etc, (2015), The Journal of Pathology
- Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling. Beckham, TH. etc, (2013), Oncogenesis
- MADD is a downstream target of PTEN in triggering apoptosis. ayarama S. etc, (2013), Journal of Cellular Biochemistry
- Loss of PTEN induces microtentacles through PI3K-independent activation of cofilin. M I Vitolo, etc, (2012), Oncogene
- Ischemic preconditioning attenuates mitochondrial localization of PTEN induced by ischemia-reperfusion. Zu L, etc, (2011), Am J Physiol Heart Circ Physiol
- N-Myc Is A Novel Regulator Of Pi3k-Mediated Vegf Expression In Neuroblastoma. Kang J, etc, (2008), Oncogene
- Akt2 Overexpression Plays A Critical Role In The Establishment Of Colorectal Cancer Metastasis. Rychahou, PG. etc, (2008), PNAS