SMAD, mothers against DPP homolog 1 (Drosophila) Adenovirus

Name 
Ad-SMAD1
Cat No 
1522
Availability
Immediate
Categories
Adenovirus, Over-Expression

Mammalian homologs of the Drosophila Mad gene include Smad1 (also designated Madr1 or JV4-1), Smad2 (also designated Madr2 or JV18-1), Smad3, Smad4 (also designated DPC4), Smad5, Smad6, Smad7 and Smad8 (also designated Smad9). Smad1 and Smad5 are effectors of BMP2 and BMP4 function while Smad2 and Smad3 are involved in TGFb and activin-mediated growth modulation. Smad4 is required for all of the above activities and necessitates FAST-1 for DNA binding. Smad6 and Smad7 regulate the response to activin/ TGF-beta signaling by interfering with TGF-beta-mediated phosphorylation of other Smad family members.

1522
Ad-SMAD1

Ready-to-use SMAD, mothers against DPP homolog 1 (Drosophila) Adenovirus. Ad-SMAD1, “SMAD, mothers against DPP homolog 1 (Drosophila)”, BSP1, JV41, JV4-1, MADH1, MADR1, SMAD1 adenovirus 1522

$690.00
Request Volume Pricing or Customization

Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
BSP-1; BSP1; JV4-1; JV41; MADH1; MADR1
Description (Vector)
SMAD1 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
Gene ID
4086
Gene Name (Vector)
SMAD family member 1
Gene Symbol
SMAD1
HGNC ID
HGNC:6767
ORF Size (aa)
1398
ORF Size (bp)
1398 bp
RefSeq ID
NM_005900
RefSeq Synonyms
NM_005900, NM_001003688, BC001878,
Species
human
UniGene ID
Hs.604588

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.