G protein-coupled receptor kinase 5 Adenovirus

Name 
Ad-GRK5
Cat No 
1493
Availability
Immediate
Categories
Adenovirus, Over-Expression

Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. This phenomenon, referred to as agonist-mediated desensitization, involves phosphorylation of the receptor by two classes of enzymes. The first is the second messenger regulated kinases such as cAMP dependent protein kinase A and protein kinase C. The second is the G protein-coupled receptor kinases (GRKs). Six members of the GRK family have been identified to date. These include rhodopsin kinase (GRK 1), two forms of beta-adrenergic receptor kinase (GRK 2 or beta-ARK 1 and GRK 3 or beta-ARK 2), IT-11 (GRK 4), GRK 5 and GRK 6. Phosphorylation of receptors by GRKs appears to be strictly dependent on the receptor being in its agonist-activated state.

1493
Ad-GRK5

Ready-to-use G protein-coupled receptor kinase 5 Adenovirus. Ad-GRK5, G protein-coupled receptor kinase 5, GRK5,GPRK5 adenovirus 1493

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
GPRK5
Description (Vector)
GRK5 encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs).
Gene ID
2869
Gene Name (Vector)
G protein-coupled receptor kinase 5
Gene Symbol
GRK5
HGNC ID
HGNC:4544
ORF Size (aa)
1773
ORF Size (bp)
1773 bp
RefSeq ID
NM_005308
RefSeq Synonyms
NM_005308, BC064506,
Species
human
UniGene ID
Hs.524625

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.