Myogenic differentiation 1 Adenovirus
Differentiation of myogenic cells is regulated by multiple positive and negative regulators. One well characterized family of helix-loop-helix (HLH) proteins known to play an important role in the regulation of muscle cell development includes MyoD, myogenin, Myf-5, Myf-6 (also designated MRF-4 or herculin) and musculin (also designated MyoR). Members of this group of transcription factors form heterodimers with products of a more widely expressed family of bHLH genes, the E family, which consists of at least three distinct genes: E2A, ITF2 and HEB. The E2A gene encodes at lest two different proteins, E12 and E47, as a result of alternative splicing. The myocyte enhancing factor-2 (MEF-2) family of transcription factors includes four splice variants A, B, C and D which encode muscle-specific DNA binding proteins that recognize an A/T rich sequence [CTA (A/T)4 TAG] localized in the control regions of numerous muscle-specific genes. This gene encodes a nuclear protein that belongs to the basic helix-loop-helix family of transcription factors and the myogenic factors subfamily. It regulates muscle cell differentiation by inducing cell cycle arrest, a prerequisite for myogenic initiation. The protein is also involved in muscle regeneration. It activates its own transcription which may stabilize commitment to myogenesis.
Ready-to-use Myogenic differentiation 1 Adenovirus. Ad-MyoD, Myogenic differentiation 1, PUM,MYF3,MYOD,MYOD1 adenovirus 1492
Gene Reference Data
Related Citations
- Expanding the Boundaries of RNA Sequencing as a Diagnostic Tool for Rare Mendelian Disease. HD Gonorazky,etc, (2019), The American Journal of Human Genetics
- MyoD transcription factor induces myogenesis by inhibiting Twist-1 through miR-206. D Koutalianos, etc, (2015), J Cell Sci
- Spell Checking Nature: Versatility of CRISPR/Cas9 for Developing Treatments for Inherited Disorders. Daria Wojtal, etc, (2015), AJHG
- FGF21 expression and release in muscle cells: involvement of MyoD and regulation by mitochondria-driven signalling. Francesc Ribas, etc, (2014), Biochem J
- Expression of miR-1, miR-133a, miR-133b and miR-206 increases during development of human skeletal muscle. Koutsoulidou A, etc, (2011), BMC Developmental Biology
- Sirt1 Controls The Transcription Of The Peroxisome Proliferator-Activated Receptor-¿ Co-Activator-1a (Pgc-1a) Gene In Skeletal Muscle Through The Pgc-1a Autoregulatory Loop And Interaction With Myod. Amat, R. etc, (2009), J. Biol. Chem