Protein kinase C, gamma Adenovirus
Members of the protein kinase C (PKC) family play a key regulatory role in a variety of cellular functions including cell growth, differentiation, gene expression, and hormone action. PKCs are protein serine/threonine kinases whose activities are dependent on calcium and phospholipids. PKCs can be subdivided into two major classes, including conventional (c) PKC isoforms and novel (n) isoforms. A more recently described member of this family has been designated either PKC µ for the human protein or PKD for isolates of mouse origin.
1454
Ad-PKC-gamma
Ready-to-use Protein kinase C, gamma Adenovirus. Ad-PKC-gamma, “Protein kinase C, gamma”, PKC-c (aka PKC-gamma) adenovirus 1454
Gene Reference Data
Alternate Names
PKC-gamma; PKCC; PKCG; SCA14
Description (Vector)
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).
Gene ID
5582
Gene Name (Vector)
protein kinase C gamma
Gene Symbol
PRKCG
HGNC ID
HGNC:9402
ORF Size (aa)
2094
ORF Size (bp)
2094 bp
RefSeq ID
NM_002739
RefSeq Synonyms
NM_002739, NM_001316329, BC047876,
Species
human
UniGene ID
Hs.631564
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.