Tumor necrosis factor (ligand) superfamily, member 10 Adenovirus

Name 
Ad-TRAIL
Cat No 
1431
Availability
Immediate
Categories
Adenovirus, Over-Expression

Programmed cell death, known as apoptosis, of nonessential cells is necessary for embryogenesis, metamorphosis, tissue turnover and proper development and function of the immune system. Apoptosis causes cytoplasmic condensation, nuclear fragmentation and membrane blebbing. There are several proteins that are responsible for the balance of signals that confer cell death and/or cell survival. Among these are the proteins of the tumor necrosis factor ligand superfamily, which includes FAS (APO-1, CD95), FAS ligand (APO-1L, CD178), TRAIL and TWEAK (APO3L) and the FAS accessory protein FAF1 (FAS-associated protein factor-1).

1431
Ad-TRAIL

Ready-to-use Tumor necrosis factor (ligand) superfamily, member 10 Adenovirus. Ad-TRAIL, “Tumor necrosis factor (ligand) superfamily, member 10”, TL2, APO2L, TRAIL, APO-2L, TNFSF10 adenovirus 1431

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
Apo-2L; APO2L; CD253; TL2; TNLG6A; TRAIL
Description (Vector)
TNFSF10 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
8743
Gene Name (Vector)
tumor necrosis factor superfamily member 10
Gene Symbol
TNFSF10
HGNC ID
HGNC:11925
ORF Size (aa)
846
RefSeq ID
NM_003810
RefSeq Synonyms
NM_003810, NM_001190943, NM_001190942, BC032722,
Species
human
UniGene ID
Hs.478275

Related Citations

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.