Myeloid differentiation primary response gene (88) Adenovirus

Name 
Ad-Myd88
Cat No 
1368
Availability
Immediate
Categories
Adenovirus, Over-Expression

Mammalian Toll-like receptors (TLRs) recognize conserved products of microbial metabolism and activate NFkB and other signaling pathways through the adapter protein MyD88. MyD88 functions as an adapter protein in the association of IL-1 receptor associated kinase (IRAK) with the IL-1 receptor. MyD88 contains a characteristic N-terminal death domain, which is essential for NF-kB activation, and an adjacent Toll/Il-1R homology domain (TIR domain), which is responsible for signal transduction. Mal (MyD88 adapter-like, also designated TIR domain-containing adapter protein (TIRAP), wyatt, or TLR-4 adaptor protein) is a cytoplasmic TIR-domain-containing protein that forms homodimers and also heterodimers with MyD88.

1368
Ad-Myd88

Ready-to-use Myeloid differentiation primary response gene (88) Adenovirus. Ad-Myd88, Myeloid differentiation primary response gene (88), Myd88 adenovirus 1368

$690.00
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Product Details

Promoter
CMV (ubiquitous)
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Titer
1x10^10 PFU/ml
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Volume (µL)
200

Gene Reference Data

Alternate Names
MYD88D
Description (Vector)
MYD88 encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants.
Gene ID
4615
Gene Name (Vector)
myeloid differentiation primary response 88
Gene Symbol
MYD88
HGNC ID
HGNC:7562
ORF Size (aa)
891
ORF Size (bp)
891 bp
RefSeq ID
NM_002468
RefSeq Synonyms
NM_002468, NM_001172569, NM_001172568, NM_001172567, NM_001172566, BC013589,
Species
human
UniGene ID
Hs.82116

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.