PPARdelta Adenovirus

Peroxisome proliferator-activated receptor delta (PPARd) belongs to the nuclear receptor superfamily, which includes the steroid hormone, thyroid hormone, retinoid, and PPAR subfamilies as well as a growing number of orphan receptors. They function as ligand-dependent sequence-specific activators of transcription. When the PPAR is activated, transcription is increased. However, PPAR can also suppress a number of genes. The function of PPARs depends on the shape of their ligand-binding domain and their co-activators and co-repressors. Ligands for the PPARs include free fatty acids and eicosanoids.

Three types of PPARs have been identified: alpha, gamma and delta. PPARd, identical to PPARb, is expressed in many tissues but markedly in brain, adipose tissue and skin. All PPARs dimerize with the retinoid X-receptor (RXR) and bind to PPREs (peroxisome proliferator response elements), which generally occurs in the promoter region of a gene. The GFP tagged to PPARd will allow the determination of the amount and location of PPARd expression.

This adenovirus contain PPARdelta with GFP.

Reference: He TC., et al., Cell. 1999 Oct 29;99(3):335-45.