FOXO3A (AAA) Adenovirus
The FKHRL1-AAA triple mutant is not phosphorylatable because three phosphorylation sites, Thr32, Ser253, and Ser315, were replaced by alanine residues.
1025
Ad-CMV-FKHRL1 (AAA)
Ready-to-use FOXO3A (AAA) Adenovirus. FKHRL1 FOXO3-AAA adenovirus 1025
Gene Reference Data
Alternate Names
AF6q21; AF6q21 protein; FKHRL1; FKHRL1P2; forkhead box O3A; forkhead box protein O3; forkhead homolog (rhabdomyosarcoma) like 1; forkhead in rhabdomyosarcoma-like 1; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; FOXO2; FOXO3A
Description (eCommerce)
Forkhead box protein 03A (FOXO3a) belongs to a large family of Forkhead proteins that possesses a winged-helix DNA-binding domain called Forkhead box (FOX). FOXO3a is a transcription factor that functions to induce apoptosis in the absence of survival factors and in response to oxidative stress. Under conditions of oxidative stress FOXO3a is acetylated and localized to the nucleus where it may act as a transcriptional repressor.
Description (Vector)
FOXO3 belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. FOXO3 likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed.
Gene ID
2309
Gene Name (eCommerce)
forkhead box O3
Gene Name (Vector)
forkhead box O3
Gene Symbol
FOXO3
HGNC ID
HGNC:3821
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2022
ORF Size (bp)
2022 bp
Protein Name (eCommerce)
Forkhead box protein O3
RefSeq ID
NM_001455
RefSeq Synonyms
NM_201559, NM_001455, BC068552, BC021224, BC020227,
Research Areas
Aging,Apoptosis,B-cell Receptor Signaling,BDNF Signaling,Cancer,Cell Cycle,DNA Damage/Repair,EGFR Signaling,EGFR Signaling in Cancer,Fc Receptor Signaling,FGF Signaling,FoxO Signaling,Glioma,IGF-1 Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,Lung Cancer,Metabolism/Metabolic Process,Neurobiology,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,Prolactin Signaling,SCF-KIT Signaling,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Translational Control
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,immunology,metabolism,neurobiology,signal_transduction,stem_cell_biology,transcription_translation
Species
human
Target Sentence
Forkhead box protein 03A (FOXO3a) belongs to a large family of Forkhead proteins that possesses a winged-helix DNA-binding domain called Forkhead box (FOX). FOXO3a is a transcription factor that functions to induce apoptosis in the absence of survival factors and in response to oxidative stress. Under conditions of oxidative stress FOXO3a is acetylated and localized to the nucleus where it may act as a transcriptional repressor.
UniGene ID
Hs.220950
UniProt ID (eCommerce)
O43524
Related Citations
- Suppression of Activated FOXO Transcription Factors in the Heart Prolongs Survival in a Mouse Model of Laminopathies. G Auguste, etc, (2018), Circulation Research
- Transcription Factor Binding Site Analysis Identifies FOXO Transcription Factors as Regulators of the Cutaneous Wound Healing Process. Karl Markus Roué, etc, (2014), PLOS One
- FOXO Transcription Factors Control E2F1 Transcriptional Specificity and Apoptotic Function. Igor Shats, (2013), Cancer Research
- Nerve Growth Factor Promotes Cardiac Repair following Myocardial Infarction. Meloni M. etc, (2010), Circulation Research
- Aldehyde Dehydrogenase-2 (Aldh2) Ameliorates Chronic Alcohol Ingestion-Induced Myocardial Insulin Resistance And Endoplasmic Reticulum Stress. Shi-Yan Li, etc, (2009), American Journal of Preventive Medicine
- Pten Regulates P300-Dependent Hypoxia-Inducible Factor 1 Transcriptional Activity Through Forkhead Transcription Factor 3a (Foxo3a). Emerling, B., etc., (2008), PNAS
- Transcription Factor Foxo3a Mediates Apoptosis In Hiv-1-Infected Macrophages. Cui, M., etc., (2008), The Journal of Immunology
- Identification Of The Prosurvival Activity Of Nerve Growth Factor On Cardiac Myocytes. Caporali, A., etc., (2008), Cell Death & Differentiation
- Forkhead Transcription Factors (Foxos) Promote Apoptosis Of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress. Senokuchi T, etc, (2008), Diabetes
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.