Akt1 Adenovirus
An HA tag was fused in frame to the N termini of the mouse Akt1 coding sequences.
Akt1/PKB is activated in response to many extracellular signals and play key roles in regulating diverse cellular processes, including cell proliferation, differentiation, apoptosis, angiogenesis and glycogen synthesis etc. Akt1 is activated by the phosphorylation of the T loop of their kinase domain by PDK1 and by phosphorylation of a residue located C-terminal to the kinase domain in the hydrophobic motif.
The Akt family of kinases includes Akt1, Akt2 and Akt3.
1022
Ad-CMV-Akt1 (wt)
Ready-to-use Akt1 Adenovirus. Akt PKB Akt1 adenovirus 1022
Related Citations
- Inhibition of the Akt1-mTORC1 Axis Alters Venous Remodeling to Improve Arteriovenous Fistula Patency. X Guo, etc, (2019), Scientific Reports
- Activity of distinct growth factor receptor network components in breast tumors uncovers two biologically relevant subtypes. Rahman M, etc, (2017), Genome Medicine
- Specific and redundant roles of PKBa/AKT1 and PKBß/AKT2 in human pancreatic islets. MG Dietrich, etc, (2015), Experimental Cell Research
- FoxO3a (Forkhead Box O3a) Deficiency Protects Idiopathic Pulmonary Fibrosis (IPF) Fibroblasts from Type I Polymerized Collagen Matrix-Induced Apoptosis via Caveolin-1 (cav-1) and Fas. Richard Seonghun Nho, etc, (2013), PLoS ONE
- Delivery Of Aav-IGF-1 To The CNS Extends Survival In ALS Mice Through Modification Of Aberrant Glial Cell Activity.. Dodge J. etc, (2008), Molecular Therapy
- Transforming Growth Factor ß1, Tumor Necrosis Factor a, And Insulin Signaling Crosstalk In Regulation Of The Rat Cholesterol 7a-Hydroxylase Gene Expression. Li, T., etc., (2008), J. Lipid Research
- Tgfß1, Tnf{Alpha}, And Insulin Signaling Crosstalk In Regulation Of The Rat Cholesterol 7{Alpha}-Hydroxylase Gene Expression. Li, T., etc., (2008), Journal of Lipid Research
- Akt2 Overexpression Plays A Critical Role In The Establishment Of Colorectal Cancer Metastasis. Rychahou, PG. etc, (2008), PNAS
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.