- January 1, 2019The transcription factor BMAL1 (aryl hydrocarbon receptor nuclear translocator-like protein 1) is an essential regulator of the circadian clock, which…
- January 1, 2019Branched-chain amino acid (BCAA; valine, leucine and isoleucine) supplementation is often beneficial to energy expenditure; however, increased circulating levels of…
- January 1, 2019Primary cilia are essential cellular organelles that are anchored at the cell surface membrane to sense and transduce signaling. Intraflagellar…
- January 1, 2019The protection of telomere ends by the shelterin complex prevents DNA damage signalling and promiscuous repair at chromosome ends. Evidence…
- January 1, 2019Pathological bone loss is caused by an imbalance between bone formation and resorption. The bone microenvironments are hypoxic, and hypoxia-inducible…
- January 1, 2019The FOXN3 gene locus is associated with fasting blood glucose levels in nondiabetic human population genetic studies. The blood glucose-modifying…
- January 1, 2019Cancer cells have higher reactive oxygen species (ROS) than normal cells, due to genetic and metabolic alterations. An emerging scenario…
- January 1, 2019Bone morphogenetic protein (BMP) and Wnt pathways regulate cell proliferation and differentiation, but how these two pathways interact and mediate…
- January 1, 2019On ocular surface, corneal epithelial stem cells (SC) reside in limbus between cornea and conjunctiva. Pax6, an evolutionally conserved transcription…
- January 1, 2019Arcuate nucleus agouti–related peptide (AgRP) neurons play a central role in feeding and are under complex regulation by both homeostatic…