Gata-6 Is A Novel Transcriptional Repressor Of The Human Tenascin-C Gene Expression In Fibroblasts
Ghatnekara, A. etc Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms,
In this study we show that GATA-6 is a novel repressor of TN-C gene expression. We demonstrated that overexpression of GATA-6 in fibroblasts inhibited basal levels, as well as markedly decreased IL-4- and TGF-ß-induced TN-C mRNA and protein levels. A GATA-6 response element was mapped to position - 467 to - 460 of the TN-C promoter. In addition, we showed that GATA-6 binds this site both in vitro and in vivo.