Gata-6 Is A Novel Transcriptional Repressor Of The Human Tenascin-C Gene Expression In Fibroblasts

Ghatnekara, A. etc
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2008


In this study we show that GATA-6 is a novel repressor of TN-C gene expression. We demonstrated that overexpression of GATA-6 in fibroblasts inhibited basal levels, as well as markedly decreased IL-4- and TGF-ß-induced TN-C mRNA and protein levels. A GATA-6 response element was mapped to position - 467 to - 460 of the TN-C promoter. In addition, we showed that GATA-6 binds this site both in vitro and in vivo.

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Journal
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Year
2008
Page
145-151
Institute
Medical University of South Carolina