Small Molecule Screening
Accelerate drug discovery with vectors tailored for precise and efficient small molecule screening.
Benefits of Using Viral Vectors
for Small Molecule Screening
Stable Gene Expression
Lentiviruses integrate into the genome, ensuring long-term target or reporter expression.
High Transduction Efficiency
Efficiently delivers genetic material to diverse cell types for consistent results.
Versatility
Easily engineered for specific targets, reporters, or regulatory elements.
Scalability
Supports large-scale production for high-throughput screening.
How Vectors Work
in Small Molecule Screening
Adeno-associated virus (AAV) is a powerful tool in small-molecule screening, particularly in the context of gene expression modulation, disease modeling, and therapeutic target validation since it has the ability to provide long-term transgene expression, low immunogenicity and increased tissue specificity for targeted screening in a wide variety of cell types and tissues.
AAV vectors can be tailored to express fluorescent and bioluminescent reporters as fusion proteins with the gene of interest or in the UTR (untranslated region). The effect of the small-molecule on the transgene will be measured as a function of the reporter expression.
AAV vectors can be tailored to express fluorescent and bioluminescent reporters as fusion proteins with the gene of interest or in the UTR (untranslated region). The effect of the small-molecule on the transgene will be measured as a function of the reporter expression.
AAV for Gene Therapy & Disease modeling
Key Applications
of Lentivirus in Small Molecule Screening
Stable Target Expression
Enables long-term expression of target genes for consistent screening results.
Reporter Gene
Introduces reporters like GFP or luciferase to monitor cellular responses to small molecules.
Pathway Analysis
Modulates specific pathways to assess small molecule effects on signaling or gene regulation.
High-Throughput Screening
Scalable production supports large-scale assays for drug discovery.
Why Use Vector Biolabs
Customizable Vectors
Offers tailored lentiviral and other viral vectors for precise gene overexpression, silencing, and editing in target validation.
High-Quality Vectors
Ensures reliability and reproducibility with rigorous quality control on all vector products.
Expertise and Support
Provides guidance and expertise to optimize experimental design and target validation processes.
Rapid Turnaround
Offer fast production and delivery times, allowing you to accelerate your clinical trial screening projects and reduce overall timelines.
Proven Safety
Our AAV vectors are non-pathogenic and trigger minimal immune responses, making them safe for clinical use.
Use Case
AAV-luciferase vectors are used to assess transcriptional activation or repression in response to small-molecule inhibitors.
The AAV vector will deliver a gene to mimic a disease model, hence bypassing the developmental time to produce a transgenic mouse model. The disease is established within a few weeks and is maintained long-term allowing to screen potential drug candidates to reverse or mitigate the disease.
The AAV vector will deliver a gene to mimic a disease model, hence bypassing the developmental time to produce a transgenic mouse model. The disease is established within a few weeks and is maintained long-term allowing to screen potential drug candidates to reverse or mitigate the disease.
