human ABCD2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human ABCD2.
shAAV-200086
AAV-h-ABCD2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human ABCD2 (ATP binding cassette subfamily D member 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ABC39; ALDL1; ALDR; ALDRP; hALDR
Description (Vector)
ABCD2 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis.
Gene ID
225
Gene Name (Vector)
ATP binding cassette subfamily D member 2
Gene Symbol
ABCD2
HGNC ID
HGNC:66
ORF Size (aa)
2223
ORF Size (bp)
2223 bp
RefSeq ID
NM_005164
RefSeq Synonyms
NM_005164, BC104903, BC104901,
Species
human
UniGene ID
Hs.117852
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.