human ABCC5 shRNA silencing AAV

Name
AAV-h-ABCC5-shRNA

Cat No
shAAV-200081

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human ABCC5.

shAAV-200081

AAV-h-ABCC5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ABCC5 (ATP binding cassette subfamily C member 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ABC33; EST277145; MOAT-C; MOATC; MRP5; pABC11; SMRP

Description (Vector)

ABCC5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.

Gene ID

10057

Gene Name (Vector)

ATP binding cassette subfamily C member 5

Gene Symbol

ABCC5

HGNC ID

HGNC:56

ORF Size (aa)

4314

ORF Size (bp)

4314 bp

RefSeq ID

NM_005688

RefSeq Synonyms

NM_005688, NM_001320032, NM_001023587, BC140771,

Species

human

UniGene ID

Hs.368563

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.