human ABCC12 shRNA silencing AAV

Name
AAV-h-ABCC12-shRNA

Cat No
shAAV-200076

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human ABCC12.

shAAV-200076

AAV-h-ABCC12-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ABCC12 (ATP binding cassette subfamily C member 12). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MRP9

Description (Vector)

ABCC12 is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. ABCC12 is a member of the MRP subfamily which is involved in multi-drug resistance. ABCC12 and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer.

Gene ID

94160

Gene Name (Vector)

ATP binding cassette subfamily C member 12

Gene Symbol

ABCC12

HGNC ID

HGNC:14640

ORF Size (aa)

4080

ORF Size (bp)

4080 bp

RefSeq ID

NM_033226

RefSeq Synonyms

NM_033226, BC148749, BC146310,

Species

human

UniGene ID

Hs.410111

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.