human CLEC4M Over-expression AAV
This is an AAV expressing Human CLEC4M.
AAV-205438
AAV-h-CLEC4M
Ready-to-use AAV expressing Human CLEC4M (C-type lectin domain family 4 member M). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD209L; CD299; DC-SIGN2; DC-SIGNR; DCSIGNR; HP10347; L-SIGN; LSIGN
Description (Vector)
CLEC4M encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. CLEC4M is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
Gene ID
10332
Gene Name (Vector)
C-type lectin domain family 4 member M
Gene Symbol
CLEC4M
HGNC ID
HGNC:13523
ORF Size (aa)
1200
ORF Size (bp)
1200 bp
RefSeq ID
NM_014257
RefSeq Synonyms
NM_014257, NM_001144911, NM_001144910, NM_001144909, NM_001144908, NM_001144907, NM_001144906, NM_001144905, NM_001144904, BC110614, BC038851,
Species
human
UniGene ID
Hs.421437
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.