human CLCNKA Over-expression AAV

Name
AAV-h-CLCNKA

Cat No
AAV-205360

Availability
4-5 weeks

This is an AAV expressing Human CLCNKA.

AAV-205360

AAV-h-CLCNKA

Ready-to-use AAV expressing Human CLCNKA (chloride voltage-gated channel Ka). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ClC-K1; CLCK1; hClC-Ka

Description (Vector)

CLCNKA is a member of the CLC family of voltage-gated chloride channels. The encoded protein is predicted to have 12 transmembrane domains, and requires a beta subunit called barttin to form a functional channel. It is thought to function in salt reabsorption in the kidney and potassium recycling in the inner ear. The gene is highly similar to CLCNKB, which is located 10 kb downstream from this gene. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

1187

Gene Name (Vector)

chloride voltage-gated channel Ka

Gene Symbol

CLCNKA

HGNC ID

HGNC:2026

ORF Size (aa)

2064

ORF Size (bp)

2064 bp

RefSeq ID

NM_004070

RefSeq Synonyms

NM_004070, NM_001257139, NM_001042704, BC053869, BC048282,

Species

human

UniGene ID

Hs.591533

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.