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human CHIT1 Over-expression AAV

Name 
AAV-h-CHIT1
Cat No 
AAV-205145
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human CHIT1.

AAV-205145
AAV-h-CHIT1

Ready-to-use AAV expressing Human CHIT1 (chitinase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CHI3; CHIT; CHITD
Description (Vector)
Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene.
Gene ID
1118
Gene Name (Vector)
chitinase 1
Gene Symbol
CHIT1
HGNC ID
HGNC:1936
ORF Size (aa)
1401
ORF Size (bp)
1401 bp
RefSeq ID
NM_003465
RefSeq Synonyms
NM_003465, NM_001270509, NM_001256125, BC105682, BC105681, BC105680, BC103695,
Species
human
UniGene ID
Hs.201688

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.