human CFI Over-expression AAV

Name 
AAV-h-CFI
Cat No 
AAV-205051
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human CFI.

AAV-205051
AAV-h-CFI

Ready-to-use AAV expressing Human CFI (complement factor I). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
AHUS3; ARMD13; C3b-INA; C3BINA; FI; IF; KAF
Description (Vector)
CFI encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene.
Gene ID
3426
Gene Name (Vector)
complement factor I
Gene Symbol
CFI
HGNC ID
HGNC:5394
ORF Size (aa)
1134
ORF Size (bp)
1134 bp
RefSeq ID
NM_000204
RefSeq Synonyms
NM_001331035, NM_001318057, NM_000204, BC020718,
Species
human
UniGene ID
Hs.312485

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.