mouse VRK2 Adenovirus

Name 
Ad-m-VRK2
Cat No 
ADV-276082
Availability
4-5 weeks
Categories
Adenovirus, Over-Expression

This is an Adenovirus expressing Mouse 1700012A03Rik.

ADV-276082
Ad-m-VRK2

Ready-to-use Adenovirus expressing Mouse Vrk2 (vaccinia related kinase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
CMV
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
2810003O05Rik; AI447698
Description (Vector)
Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes, reduces JNK phosphorylation and AP1-dependent transcription. Phosphorylates: 'Thr-18' of p53/TP53, casein, MBP, histone H2B, histone H3 and MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS|Function: Isoform 2 phosphorylates: 'Thr-18' of p53/TP53, casein, MBP, histone H2B, histone H3 and MAPK8IP1. Stabilizes p53/TP53 and activates its transcriptional activity. Reduces p53/TP53 ubiquitination by MDM2 and promotes its acetylation by EP300.
Gene ID
69922
Gene Name (Vector)
vaccinia related kinase 2
Gene Symbol
Vrk2
ORF Size (aa)
1365
ORF Size (bp)
1365 bp
RefSeq ID
NM_027260
RefSeq Synonyms
NM_027260, NM_001252447, BC013520,
Species
mouse
UniGene ID
Mm.285351

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.