mouse TNK2 Adenovirus
This is an Adenovirus expressing Mouse Tnk2.
ADV-274750
Ad-m-TNK2
Ready-to-use Adenovirus expressing Mouse Tnk2 (tyrosine kinase, non-receptor, 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Ack; Ack-1; Ack1; Cdgip; Pyk1
Description (Vector)
Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR.
Gene ID
51789
Gene Name (Vector)
tyrosine kinase, non-receptor, 2
Gene Symbol
Tnk2
ORF Size (aa)
3027
ORF Size (bp)
3027 bp
RefSeq ID
NM_016788
RefSeq Synonyms
NM_016788, NM_001347185, NM_001289443, NM_001110147, BC052421, BC031168,
Species
mouse
UniGene ID
Mm.251115
Recently Viewed Products
AAV-m-EGR2-shRNA
Cat No: shAAV-258148
Ad-h-HIST1H2AB-shRNA
Cat No: shADV-211066
AAV-CAG2-DIO-RFP
Cat No: VB1360
Ad-h-VSTM1
Cat No: ADV-227564
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.