mouse TEAD4 Adenovirus
This is an Adenovirus expressing Mouse Tead4.
ADV-274008
Ad-m-TEAD4
Ready-to-use Adenovirus expressing Mouse Tead4 (TEA domain family member 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ETFR-2; Etfr2; FR-19; Rtef1; Tcf13r1; TEAD-4; TEF-3; Tef3; Tefr; Tefr1; Tefr1a
Description (Vector)
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif.
Gene ID
21679
Gene Name (Vector)
TEA domain family member 4
Gene Symbol
Tead4
ORF Size (aa)
1155
RefSeq ID
NM_011567
RefSeq Synonyms
NM_011567, NM_001080979, BC130257,
Species
mouse
UniGene ID
Mm.14774
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.