mouse TAP2 Adenovirus
This is an Adenovirus expressing Mouse Tap2.
ADV-273693
Ad-m-TAP2
Ready-to-use Adenovirus expressing Mouse Tap2 (transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ABC18; Abcb3; AI462429; APT2; Ham-2; Ham2; jas; MTP2; PSF2; RING11; Tap-2; Y1
Description (Vector)
Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association.
Gene ID
21355
Gene Name (Vector)
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Gene Symbol
Tap2
ORF Size (aa)
2109
ORF Size (bp)
2109 bp
RefSeq ID
NM_011530
RefSeq Synonyms
NM_011530, BC051257, BC005578,
Species
mouse
UniGene ID
Mm.14814
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.