mouse SENP6 Adenovirus
This is an Adenovirus expressing Mouse Senp6.
ADV-271611
Ad-m-SENP6
Ready-to-use Adenovirus expressing Mouse Senp6 (SUMO/sentrin specific peptidase 6). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2810017C20Rik; E130319N12Rik; mKIAA0797; Susp1
Description (Vector)
Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
Gene ID
215351
Gene Name (Vector)
SUMO/sentrin specific peptidase 6
Gene Symbol
Senp6
ORF Size (aa)
2526
ORF Size (bp)
2526 bp
RefSeq ID
NM_146003
RefSeq Synonyms
NM_146003, NM_001311110, BC172171, BC151128, BC061480,
Species
mouse
UniGene ID
Mm.28232
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.