mouse RIC8 Adenovirus

Name
Ad-m-RIC8

Cat No
ADV-270588

Availability
4-5 weeks

This is an Adenovirus expressing Mouse Ric8a.

ADV-270588

Ad-m-RIC8

Ready-to-use Adenovirus expressing Mouse Ric8a (RIC8 guanine nucleotide exchange factor A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

AI114950; RIC-8; Ric8

Description (Vector)

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.

Gene ID

101489

Gene Name (Vector)

RIC8 guanine nucleotide exchange factor A

Gene Symbol

Ric8a

ORF Size (aa)

1593

ORF Size (bp)

1593 bp

RefSeq ID

NM_053194

RefSeq Synonyms

NM_053194, BC022917,

Species

mouse

UniGene ID

Mm.281916

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.