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human CALD1 Over-expression AAV

Name 
AAV-h-CALD1
Cat No 
AAV-203965
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human CALD1.

AAV-203965
AAV-h-CALD1

Ready-to-use AAV expressing Human CALD1 (caldesmon 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
caldesmon; CDM; HCAD; H-CAD; LCAD; L-CAD; NAG22; testis secretory sperm-binding protein Li 227n
Description (eCommerce)
Caldesmon is a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of caldesmon possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction [taken from NCBI Entrez Gene (Gene ID: 800)].
Description (Vector)
CALD1 encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
Gene ID
800
Gene Name (eCommerce)
caldesmon 1
Gene Name (Vector)
caldesmon 1
Gene Symbol
CALD1
HGNC ID
HGNC:1441
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1617
ORF Size (bp)
1617 bp
Protein Name (eCommerce)
Caldesmon
RefSeq ID
NM_004342
RefSeq Synonyms
NM_033157, NM_033140, NM_033139, NM_033138, NM_004342, BC040354,
Research Areas
Cardiovascular,Cytoskeleton,EGFR Signaling,Neurobiology,Signal Transduction
Research Areas (Faceted)
cardiovascular,signal_transduction,cell_biology,neurobiology
Species
human
Target Sentence
Caldesmon is a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of caldesmon possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction [taken from NCBI Entrez Gene (Gene ID: 800)].
UniGene ID
Hs.490203
UniProt ID (eCommerce)
Q05682

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.