mouse NUAK1 Adenovirus
This is an Adenovirus expressing Mouse Nuak1.
ADV-266162
Ad-m-NUAK1
Ready-to-use Adenovirus expressing Mouse Nuak1 (NUAK family, SNF1-like kinase, 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AU014801; AW494241; B230104P22Rik; Omphk1
Description (Vector)
Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating phosphorylation of PPP1R12A subunit of myosin PP1: phosphorylated PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in DNA damage response: phosphorylates p53/TP53 at 'Ser-15' and 'Ser-392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR.
Gene ID
77976
Gene Name (Vector)
NUAK family, SNF1-like kinase, 1
Gene Symbol
Nuak1
ORF Size (aa)
1977
ORF Size (bp)
1977 bp
RefSeq ID
NM_001004363
RefSeq Synonyms
NM_001004363, BC082328,
Species
mouse
UniGene ID
Mm.25874
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.