mouse MSH3 Adenovirus

Name
Ad-m-MSH3

Cat No
ADV-265045

Availability
4-5 weeks

This is an Adenovirus expressing Mouse Msh3.

ADV-265045

Ad-m-MSH3

Ready-to-use Adenovirus expressing Mouse Msh3 (mutS homolog 3). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

CMV

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

D13Em1; Rep-3; Rep3

Description (Vector)

Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta which binds to DNA mismatches thereby initiating DNA repair. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. MutS beta recognizes large insertion-deletion loops (IDL) up to 13 nucleotides long. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis.

Gene ID

17686

Gene Name (Vector)

mutS homolog 3

Gene Symbol

Msh3

ORF Size (aa)

3288

ORF Size (bp)

3288 bp

RefSeq ID

NM_010829

RefSeq Synonyms

NM_010829, NM_001311120, BC150759,

Species

mouse

UniGene ID

Mm.343101

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.