mouse MRE11A Adenovirus
This is an Adenovirus expressing Mouse Mre11a.
ADV-264867
Ad-m-MRE11A
Ready-to-use Adenovirus expressing Mouse Mre11a (MRE11A homolog A, double strand break repair nuclease). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Mre11; Mre11b
Description (Vector)
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
Gene ID
17535
Gene Name (Vector)
MRE11A homolog A, double strand break repair nuclease
Gene Symbol
Mre11a
ORF Size (aa)
2121
ORF Size (bp)
2121 bp
RefSeq ID
NM_018736
RefSeq Synonyms
NM_018736, NM_001310728, BC065144,
Species
mouse
UniGene ID
Mm.149071
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.